Once I approached Neighbor Mountain from Skyline Drive, and continued cross-country along the ridge to Three Sisters and back. The ridge was very pleasant. I have also done it as a loop including Knob Mountain.
My last mountain of 2011. I hiked it from the valley floor outside the park. It was a good hike. On the way back, the crossing of Jeremy's Run turned out to be pretty difficult, and my feet were soaked. Same thing happened to the other hikers I talked to, so it wasn't just my klutziness.
Done it a couple of times from the bottom by starting outside the park and going up the Jeremy's Run Trail. There used to be a fire foot trail that came into the AT a bit north of where the Neighbor Mountain Trail hits it that would take you back down to the Jeremy's Run Trail; you can still bushwhack it.