Don't worry about route numbers. They will just confuse you.
Turn immediately south from I-81 exit 35. Follow the major two lane White Top Road 11 miles until you cross a small bridge and come to an intersection. Look for a sign that says "White Top Road" and "Elk Garden" on the left. Turn left. Continue up the major two lane white top road another 5 miles to the trail head.
"After the first glass, you see things as you wish they were. After the second, you see things as they are not. Finally, you see things as they really are, which is the most horrible thing in the world."
--Oscar Wilde on Absinthe