As long as you have the standard OAE Truck clearance you should be fine w/2wd.
If you take the standard route via Buttermilk Rd, it is gonna be real rough and terribly bouncy. The alternate access up off of 168 heading up to Aspendale/Sabrina etc is much less traveled and not as harsh as the BMilk way. (PM me and I can give more specific instructions on how to access this alternate route).
Alois can attest to this.