For driving instructions to the trailhead refer to the Devils, Flume, Pollock Bench, and Rattlesnake Canyon Trails portion of the Getting There section. Note that Rattlesnake Arches can also be accesed from the south (refer to Rattlesnake Arches and Mee Canyon Trails portion of the Getting There section). This option would greatly reduce the length of the hike, however it would greatly increase the driving time if you're coming from the Grand Junction area. I personally would rather spend my time hiking rather than driving.
The hike begins near the Colorado River and steadily climbs towards Rattlesnake Canyon. The scenery is rocky with scraggly pine trees and low shrubs. As you climb toward Rattlesnake Canyon there are a few arroyos that you must descend down into and climb up the other side. Climbing in and out of arroyos while steadily gaining elevation continues for 7 miles before you reach the east rim of Rattlesnake Canyon. The trail gains approximately 1000' between the trailhead and Rattlesnake Canyon.
When you reach Rattlesnake Canyon, the trail takes an abrupt southward turn and you are presented with two spectacular views. Off to the west is breathtaking Rattlesnake Canyon. Just above your head to the east are Rattlesnake Arches, which rival those of Arches National Park. The trail runs directly below a series of natural arches that continues along the east rim of the canyon for a few miles.
Only standard hiking gear is necessary. Rock climbing shoes might be nice for horsing around on the arches. During hot weather, make sure to pack lots of water—there are no reliable sources of water along the way.