Aiguille Blanche de Peuterey without doubt, as even from the normal route is still a very serious, long and complex climb. Also, the recent changes is the configuration of the Freney glacier has made access to the Schneider Ledges and/or the Craveri hut even more complex. Actually, it's now thought in some quarter than access via the descent from the Aiguille Noire is probably more reasonable!
The Aiguille Blanche is the most difficult independent peak of the Alps - the most inaccessible and serious (but not so well defined as a peak) may be Pic Luigi Amedeo on the Brouillard Ridge of Mt. Blanc.