Blood plasma is mostly water, perhaps it is due to dehydration, and not the altitude itself.
I read about a fatality in Death Valley a few years ago, the guy collapsed less than 1/2 mile from his vehicle. The article explained he likely passed out due to being so dehydrated his blood thickened and couldn't get enough oxygen to his brain- if I am remembering correctly.
I'm sure someone will have a better, more technical, explanation later.