To bump the previous posts, it's unlikely you will see them even if they're there.
I used to live in America's Finest City and spent many a weekend away from the beach and in the mtns. At one time (don't know if it's still active) Cuyamaca Rancho ran an extensive mtn lion study program (tracking, etc...) and if they still do, those guys may be around and can provide all kinds of info. You can check w Park Service to see if study is still going on.
Basically risk is very minimal considering they are just elusive by nature. One other reason they are so rare is their territory, particularly for the males, is huge >100SqMi so you wouldn't have a lot of lions in any particular area. From what the program guys said, they would be most prominent in Pine Valley, Lagunas, Cuyamaca area but do reach as far south as Campo, as far east as Hellhole Canyon/Ranchita and north to Riverside County line and beyond. Areas with hobby animals like llamas and of course plentiful mule deer are where they would be found. All that being said, with all the daytrips, the only lion I've ever seen in SoCal was Whiting Ranch, OC back around 2001/2002 and that area has, unfortunately, become synonymous with lions.
Just be a little more aware at dawn/dusk when they are active, and if you have an encounter, make yourself as large as possible, hold hands up and make a lot of noise. Don't crouch and don't run. Like WY said if it came down to it, fight hard, go for the snout and eyes.
As all are seemingly in agreement, you've got more chance of coming to my town and winning a couple cars on the slots than being attacked.
Have fun! There are unbelievable areas in SD and I don't get back as much as I'd like...